Delayed (non-IgE mediated) food allergies

Delayed (non-IgE mediated) food allergies

There are two types of food allergy; which type depends on whether or not the allergic reaction is triggered by an antibody called immunoglobulin E (usually called IgE). These antibodies are the chemical signals that set off an acute (sudden) allergic reaction. Dealyed non-IgE mediated food allergies are caused by a reaction involving other components of the immune system apart from IgE antibodies. The reactions do not appear immediately, often taking longer to develop (hours to days).


Symptoms can include one or more of the following:

  • dry, itchy and red skin (eczema)
  • abdominal discomfort or colic during infancy
  • reflux (vomiting) or silent reflux (pain)
  • diarrhoea, mucous or blood in stools
  • poor weight gain
  • more rarely, constipation

We most commonly see delayed (non-IgE mediated) food allergies in infants in the first few months of life. Through detailed history taking, examination, and where appropriate allergy testing, I will assess whether you child is likely to have these symptoms because of a food allergy or because of another condition. I will provide the next steps on how to confirm whether these symptoms  are being driven by a delayed food allergy (usually by exclusion of the offending food followed by reintroduction). We ensure that any changes to the diet that we make at this time in the infant or maternal diet (whilst breastfeeding), do not lead to any nutritional deficiencies.

Dr Brough has been proactive and incredibly thorough with investigating our baby son’s allergies. She has provided supporting information and resources which are helpful tools for managing the situation. Her responses to my questions have been informative and she has been very responsive, ensuring I’m equipped with essential and accurate information. I’m so pleased that our son is under her care.

COVID-19 Notice

Children’s Allergy Doctors are able to offer face-to-face appointments including allergy testing during the COVID-19 outbreak.

We are also able to offer telephone and secure video consultations. Prescriptions can be delivered directly to your home.

We wish you all good health and stay safe!